Pricing
Project-based pricing. No surprise invoices.
Each tier is a fixed-fee engagement with a defined deliverable. Gene editing programs typically range from $150K to $400K depending on scope. Add-on wet-lab support and custom model training are quoted per scope.
Guide Design
$150K
10 days delivery
Single locus CRISPR guide screening, up to 500K variants
- Genome-wide guide screening
- Off-target risk classification
- Ranked guide list (top 10–20)
- Validation playbook
- Manufacturing-ready files
- Email support
Most popular
Full Optimization
$280K
12–14 days delivery
Base editing or codon optimization with edit simulation
- Everything in Guide Design
- Bystander edit or expression prediction
- Tissue chromatin weighting
- Edit outcome simulation report
- Priority support
- Two revision rounds
Enterprise
Custom
Flexible delivery
Multi-locus panels, custom models, integration with client data
- Everything in Full Optimization
- Dedicated project manager
- Multi-locus guide panel design
- Custom edit outcome model training
- Regulatory dossier support
- Indemnification & SLAs
Typical engagement range: CRISPR guide design $150K–$280K · Base editing optimization $200K–$320K · AAV codon optimization $250K–$400K. Wet-lab validation support, multi-locus panels, and custom edit outcome models quoted separately.
Frequently asked questions
- How accurate are your edit predictions?
- Across closed engagements, top-ranked guides and constructs have shown 85 to 95 percent wet-lab confirmation rates for on-target editing and expression, substantially above manual design approaches (typically 50 to 70 percent) because we calibrate scoring against proprietary validation datasets.
- What file formats do you accept?
- FASTA for target sequences and constructs, BED for genomic coordinates, GenBank for full plasmid designs, and structured CSV for prior edit outcome data. We can also start from a gene symbol and GRCh38 coordinates.
- Can you integrate with our internal sequence databases?
- Yes. On Full Optimization and Enterprise tiers we support secure data transfer, on-prem deployment for sensitive IP, and direct connectors to common LIMS and ELN systems.
- What's your typical success rate in wet-lab validation?
- Across CRISPR guide and base editing engagements, the median client reports acceptable on-target activity in 80 percent or more of the top 5 guides we deliver. Codon optimization clients typically see 3× or greater expression improvement vs. prior constructs.
- Do you sign IP and confidentiality agreements?
- Always. We sign a mutual NDA before any technical discussion and assign all generated IP to the client by default.